Blog

PET Dynamic Imaging, Kinetic Analysis & %RO
Posted by Mario Bourdon | May 1, 2021
PET Brain Receptor Occupancy Analysis: Part 3, RO Assay Basics

PET receptor occupancy analysis is a type of radiotracer tracer study that measures the change in receptor occupancy of a radiotracer caused by the test drug. The radiotracer defines 100%...

Posted by Mario Bourdon | April 19, 2021
PET Brain Receptor Occupancy – Part 2: The role of the Blood Brain Barrier

One of the biggest challenges to doing brain receptor occupancy is the blood brain barrier (BBB). Before the receptor ligand (PET radiotracer) can find the target receptor it has to...

Posted by Mario Bourdon | April 11, 2021
PET Brain Receptor Occupancy Analysis: Part 1, Getting Started

Therapeutic drugs targeting a wide range of central nervous system (CNS) disorders work by interacting with CNS receptors. Developing those drugs inevitably leads to needing to understand Drug/ Receptor PK/PD...

Posted by Mario Bourdon |
Cell Imaging PK/Biodistribution

The tracking of cells in vivo is a critical aspect of any cell-based therapy research program. Whether tracking stem cells, T-cells, or exotics like platelets, liposomes, and reporter gene constructs...

Posted by Mario Bourdon |
Microbubble Tumor Screening Part 2

TN targeted microbubble localization in 786-0 tumor xenograft (untargeted left panel, tenascin targeted min right panel) This article is part two in a two-part series. Go here to read part...

Figure 1 Untargeted TAC (control: yellow, tumor: green)
Posted by Mario Bourdon |
Microbubble Multi-parametric in vivo Screening of Tumor Xenografts

TN targeted microbubble localization in 786-0 tumor xenograft (untargeted left panel, tenascin targeted min right panel) This article is part one in a two part series. Go here to read...

Ultrasound Cardiac Strain Analysis
Posted by Mario Bourdon |
Echocardiography Model of Cardiomyopathy

Ultrasound Cardiac Strain Analysis Cardiomyopathy is a significant clinical condition that is progressive and can be fatal. The development of new investigative therapeutics requires animal models that reproduce the disease....

photo-of-doctor-with-medical-HUD
Posted by Mario Bourdon |
Function Imaging in Safety/Toxicology

Many drugs have off target toxicity at lower concentrations or with chronic exposures that are undetected in standard preclinical GLP tox studies. What is often required are in vivo function...

Posted by Mario Bourdon |
NASH Ultrasound Imaging

CDAHFD Mouse Liver (Ultrasound) BioLaurus and Triangulum Bioscience have collaborated to develop an Ultrasound method to measure NASH in the CDAHFD model of liver fibrosis in mice. Age matched mice...

NHP Platelet Sequestration (pre and post drug treatment)
Posted by Mario Bourdon |
Drug Induced Thrombocytopenia: PK Analysis

NHP Platelet Sequestration (pre and post drug treatment) A wide range of drugs from heparin, to small molecules, antisence-oligonucleotides (ASA), peptides, and biologics have been found to reduce platelet (PLT)...

Rat Brain CFN. Molecular Imaging Study
Posted by Mario Bourdon |
Opioid Receptor Occupancy PK

Rat Brain CFN BioLaurus has developed multiple PET PK assays in rats. We are experts in the development of CNS PK assays and determination of the in vivo PK profile...